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This list of capstones is provided to assist students who are planning their honors capstone. Full-text of selected capstones are linked to Digital Commons. Some majors from the former SPSU have been discontinued, so look in related majors to find capstones that might apply to you. Vande Corput,Spring By Ashley Brooks, Spring


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ARNOLD J STROMBERG, Ph.D. CURRICULUM VITAE 2018-06-29¢ Stromberg ARNOLD J STROMBERG,...


The primary goal of the society was to promote and disseminate the knowledge and understanding acquired by its members, and to strengthen interactions between them.

Since then, the society holds its annual meeting every year in Eilat usually during December. At this annual meetings, the senior Israeli neurobiologists, their teams, and their graduate students, as well as foreign scientists and students, present their recent research findings in platform and poster presentations, and the program of the meeting is mainly based on the received abstracts which are published in this volume.

The meeting also offers the opportunity for the researchers to exchange information with each other, often leading to the initiation of collaborative studies. Both the number of members of the society and those participating in the annual meeting is constantly increasing, and it is anticipated that this year about scientists will convene at the Princess Hotel in Eilat, Israel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Aggregation of the amyloid-beta A-beta peptide in the extracellular space of the brain is central to Alzheimer's disease AD pathogenesis. Recent findings have shown that synaptic activity promotes release of A-beta through vesicle exocytosis. However, the relationship between vesicular release of A-beta and neurotransmitter release remains obscure. Current hypothesis of AD suggests that elevated neuronal activity leads to increased extracellular concentration of A-beta, which in turn triggers reduction in the number, strength, and plasticity of synaptic connections, eventually resulting in memory impairments.

According to this hypothesis, decreased synaptic activity should promote memory function through reducing A-beta level. However, on the other hand, memory-related forms of synap-tic plasticity are manifested as increase in synaptic activity.

To understand this paradox, we study the relationship between different patterns of synaptic activity, A-beta release, and synaptic transmission using FM-based functional imaging at the level of single synapse and in synaptic networks. Our results show that acute accumulation of endoge-nously released A-beta enhances presynaptic activity for single spikes that mimic background activity through increasing release probability and the number of functional presy-naptic terminals.

However, A-beta does not affect presy-naptic activity associated with temporally correlated burst of spikes. These results suggest that A-beta might be a key molecule transforming hippocampal synapses to a low-pass filter mode, resulting in decreased short-term facilitation of transmitter release during bursts. We hypothesize that elevation of background presynaptic activity by A-beta might be a trigger for homeostatic down-regulation in the number and plasticity of synapses and, eventually, memory decline in AD.

Protective effect of N-acetyl-L-Carnosine, a lipophilic derivative of L-Carnosine, on lipopolysaccaride-induced glial oxidative stress. Neurodegenerative disorders pathology can be characterized by both chronic inflammation and oxidative stress. The most dominant source of inflammatory and oxidative stress mediators like nitric oxide NO , prostaglandins, and cytokines are activated microglia.

We used lipopolysaccharide LPS in order to induce oxidative stress in microglia. L-Carnosine is known as an efficient endgenous antioxidant. The aim of this. Our results suggest that L-Carnosine and NACar may play a protective role in oxidative stress process in the brain. Further studies are needed aiming to understand the mechanism by which L-Carnosine and NACar act and to use these compounds as a potential treatment strategy for strategy for neu-rodegenerative diseases. Nitric oxide NO is produced in the brain by both neurons and astrocytes.

Until recently, astrocytic NO production has been demonstrated mainly as a slow reaction to detrimental events through the activity of an inducible NOS isoform iNOS. Prior data from our laboratory described for the first time rapid astrocytic NO release in brains of healthy animals. Evaluation of the mutants' behavior in several behavioral tests revealed increased anxiety-like responses, with no differences in motor activity Buskila et al.

To further characterize the behavioral phenotype, we compared the performance of mutant mice to their controls in their response to stress. Seven days after exposure to predator scent stimulation PSS , mutants exhibited higher anxiety-like behavior in the elevated-plus maze and stronger acoustic startle response. No such differences between groups were observed without the stress exposure.

Plasma corticosterone levels were significantly higher in mutant mice following PSS, further demonstrating their heightened sensitivity to stress. Interestingly, mutant mice performed better on the Morris water maze MWM under control conditions. The possibility of improved cognition in these mice was not supported as these mutants failed to show improved performance in the object recognition test.

The MWM results are probably due to enhanced motivation under water maze stress conditions in mutant mice compared to controls.

Taken together, our results confirm higher susceptibility to stressful conditions in an astrocytic NOS mouse mutant. The role of CB1 receptors in the hippocampus and nucleus accumbens in extinction learning and neural plasticity. The inability to extinguish maladaptive fear responses is a hallmark of anxiety disorders, particularly posttraumatic stress disorder.

Thus, suppression of the fear response via the behavioral paradigm of extinction receives increasing attention, since it could become an effective intervention for treating fear-related disorders. The endocannabinoid system, particularly CB1 receptors, has recently emerged as considerably important in the extinction of fear-related learning.

However, interest in their therapeutic applications has been restrained by potentially harmful consequences on memory. Given the well-established role of the hippocampus in learning and memory processes, it is likely that the adverse effects of cannabinoids on memory are attributable to their actions within this brain region.

The nucleus accumbens represents a brain area that is critical to the expression of rewarding and addictive properties of several classes of abused drugs including cannabinoids. Thus, we set out to examine the role of CB1 receptors in extinction learning and plasticity in the hippocampal-accumbens pathway. We found that microinjecting the CB1 antagonist AM 0.

However, the direct cannabinoid agonist WIN 55 0. These observations are consistent with cannabinoid effects on memory, and suggest a twofold effect of cannabinoids on memory within the hippocampus: impairing and facilitating. This effect seems to be dependent on the memory task under examination. Fine mapping of a schizophrenia susceptibility locus on chromosome 10qq significant evidence for linkage and a reduced linkage interval.

A genome scan for schizophrenia related loci in Arab Israeli families detected significant evidence for linkage at chromo-. Subsequent fine mapping, association, and replication studies identified AHI1 as a putative susceptibility gene.

The same genome scan revealed suggestive evidence for a schizophrenia susceptibility locus in the 10q region. To refine the linkage interval on chromosome 10q and to seek candidate genes in this region, we genotyped 35 additional microsatellite markers in the previously studied Arab Israeli sample, covering a Linkage and haplotype analyses were performed. The strength of the linkage on chromosome 10q increased from a multipoint, parametric HLOD score of 2. The one-unit support interval surrounding this peak decreased from In addition 26 out of 41 affected individuals were found to share the same haplotype, which consists ofD10S88 and D10S markers.

This study revealed significant evidence for linkage of Arab Israeli families affected with schizophrenia to chromosome 10q Haplotype analysis suggests a founder mutation between markers D10S and D10S 10q There are 17 protein-coding genes in HLOD-1 region and most of them are brain-expressed with potential pathophysiological relevance to schizophrenia.

These findings are supported by those of Levinson et al. Transmembrane protein mechanisms such as ion channels and their activity are at the essence of neuronal transmission. The most accurate method, so far, for determining ion channel kinetic mechanisms is single-channel recording and analysis. Nevertheless, single-channel recordings carry several holdups and complexities, especially when dealing with voltage-gated channels.

We have previously developed a method for fitting cell-attached and whole-cell voltage-clamp data to kinetic models of ion channels using genetic search algorithms GAs. Here, we show the application of this method for testing several previously published and newly conceptualized kinetic models to voltage-gated.

The results emphasize the inability of the commonly used Hodgkin-Huxley paradigm to match and reproduce recorded currents from mammalian cortical neurons. Further, initial tests suggest a trend towards a simplified Markov scheme that adequately reproduces measured sodium currents. Finally, experiments were performed to test the robustness of the best putative Markov models, using Monte Carlo simulations.

Haplotypes and haplogroups are linked sets of common DNA variants, acting as susceptibility or protective factors to complex disorders. Growing evidence suggests that dysfunction of mitochondrial bioenergetics contributes to the schizophrenia phenotype. We studied mitochondrial DNA haplogroups in schizophrenia patients.

Since mitochondria are inherited from the mothers, we used healthy fathers as an ideal case-control group. Since mitochondrial DNA is small relative to nuclear DNA, a total mitochondrial genome analysis was possible in a hypothesis-free manner.

However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups. Perception from a blind perspective: multisensory integration and sensory substitution in blind and sighted individuals.

Restoration of sight in a blind person imposes great clinical and scientific challenges. Despite intensive efforts, recovery of vision using neuroprostheses has not been achieved.

A major reason for this failure might be that the brain in the blind undergoes profound plastic changes and we do not know enough about vision and about how to communicate with this altered cortex to generate meaningful visual perception.

In this presentation, new findings regarding the nature of sensory representations and verbal memory information in sighted, blind, and week long blindfolded subjects will be presented. These studies show that interactions between sensory modalities are critical to our understanding of sensory perception in the brain. These findings also show that massive brain plasticity in the occipital cortex is possible during development but possible even in the adult visual cortex.

Here, I will highlight the role of transcranial magnetic stimulation TMS as a tool to assess the functional relevance of these plastic changes. Finally, I will discuss the use of sensory substitution devices SSDs in the context of blindness. In SSDs, visual information captured by an artificial receptor is delivered to the brain of a blind person using nonvisual sensory information via a human-machine interface. I will show that the use of an auditory-to-visual sensory substitution device called "the vOICe" yields successful performance on object recognition tasks, and specific recruitment of ventral and dorsal visual structures both in blind and sighted experts.

I will close by discussing the importance of "the vOICe" as a device to be used for daily activities e. Converging evidence from numerous ERP and MEG studies points to a neural response which discriminates faces from nonface objects, peaking at around milliseconds following stimulus onset. Here we ask whether this discrimination at the neural level correlates with conscious detection of a face, or with its mere presence in the visual field.

To investigate this, we used "continuous flash suppression," a binocular rivalry technique that effectively causes unawareness of the stimulus presented to one eye.

In each trial, a face or an Easter egg was continuously presented to one eye, but was temporarily masked after a delay by a dynamic stimulus presented to the other eye. In a control condition, the face or egg was physically removed for the duration of the dynamic mask. In both conditions, the subjects' subjective experience was of two presentations of a face or of an egg.

The onset of the first face elicited a typical N face-specific response in both conditions. In contrast, the subjective reappearance of the face elicited a face-specific N response only in. Thus, extrastriate object-selective responses reflect the physical presence of relevant input, and are not correlated with conscious awareness. The effects of withdrawal from chronic administration of estradiol on "compulsive" lever-pressing of female rats—a preliminary study. Sex differences have been found in the phenomenology and course of this disorder, and women have been reported to be vulnerable to an onset or exacerbation of symptoms during premenstruum, pregnancy and postpartum.


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She also talks with Laura Koehly — a senior investigator at the National Human Genome Research Institute, with a special interest in helping people unlock the information hidden in their family health histories, particularly focusing on underserved and less privileged communities. Genetics Unzipped is the podcast from The Genetics Society. Full transcript, links and references available online at GeneticsUnzipped. Subscribe from Apple podcasts, Spotify , or wherever you get your podcasts.

The simulation results indicate that the finite element simulation can and Optimal Control in Swing-Free Transfer of Suspended Load," in Proceedings of.

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UCI encourages its students and helps them pursue their dreams. I cannot express. My appreciation also goes to the Undergraduate Research Opportunities Program team for organizing this symposium,. This year marks the publication of. This award recognizes the outstanding contributions. Along with the entire UCI community, I of fer my. Thank you for joining us in this celebration of the learning that accompanies research. Schedule of Events A Welcome from Undergraduate Education Keynote Speaker

Capstones by Majors

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Professor and Chair Email: astro11 email. Gonzalez, O. Activation of Notch-1 in oral epithelial cells by P. Mucosal Immunol, 1 , S Ebersole, J.

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A request by KG who also provided lots of useful information and a schematics for this. Info about the circuit HERE. Now it is 26 cuts. Forgot to add a cut between pin 1 and 8 at IC3. It's coming along nicely so far

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Try out PMC Labs and tell us what you think. Learn More. The primary goal of the society was to promote and disseminate the knowledge and understanding acquired by its members, and to strengthen interactions between them. Since then, the society holds its annual meeting every year in Eilat usually during December. At this annual meetings, the senior Israeli neurobiologists, their teams, and their graduate students, as well as foreign scientists and students, present their recent research findings in platform and poster presentations, and the program of the meeting is mainly based on the received abstracts which are published in this volume.

Such communications, for example, may enable loading of the software from one that can be analyzed using random matched motif data simulation algorithm.

Hi Just curious as to whether this same recipe could be used with other flavor oils such as maybe peppermint, licorice anise, lemon, or any berry flavor with appropriate food color to match?? This usually has little effect because patients do not exercise during the flight. In case of multiple carbonyl types in one molecule, one can expect the most electrophilic carbonyl carbon to react first.

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Pages Page size x pts Year With its focus on the human organism, Quirks of Human Anatomy opens the floodgates by stating the arguments of evo-devo in plain English and by offering a cornucopia of interesting case studies and examples. Its didactic value is enhanced by 24 schematic diagrams that integrate a host of disparate observations, by its Socratic question-and-answer format, and by its unprecedented compilation of the literature.




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