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Health-promoting effects of traditional Mediterranean Diets View all 4 Articles. Although AD and PD have different clinical and neuropathological features, they share common molecular mechanisms that appear to be triggered by multi-factorial events, such as protein aggregation, mitochondrial dysfunction, oxidative stress OS , and neuroinflammation, ultimately leading to neuronal cell death. Currently, there are no established and validated disease-modifying strategies for either AD or PD. Among the various lifestyle factors that may prevent or slow age-related neurodegenerative diseases, epidemiological studies on moderate consumption of red wine, especially as part of a holistic Mediterranean diet, have attracted increasing interest. Red wine is particularly rich in specific polyphenolic compounds that appear to affect the biological processes of AD and PD, such as quercetin, myricetin, catechins, tannins, anthocyanidins, resveratrol, and ferulic acid. Indeed, there is now a consistent body of in vitro and in vivo data on the neuroprotective effects of red wine polyphenols RWP showing that they do not merely possess antioxidant properties, but may additionally act upon, in a multi-target manner, the underlying key mechanisms featuring in both AD and PD.

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• Mystère CA21 Line Preamplifier & PA21 Power Amplifier (TAS 208)
• Carrier reefer oil capacity
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• Jeffrey J. Wine
• Vincent Audio SA-31MK Hybrid Linestage Preamplifier & SP-331MK Hybrid Power Amplifier (TAS 208)
• Apple’s warranty advertising comes under EU’s microscope
• TESCOMA 654006 CLASSIC SALT & PEPPER SET (LIQUIDATION)
• Audio Reviews by Year
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Mystère CA21 Line Preamplifier & PA21 Power Amplifier (TAS 208)

The Journal of Innovation and Knowledge JIK focuses on how we gain knowledge through innovation and how knowledge encourages new forms of innovation. Not all innovation leads to knowledge. Only enduring innovation that can be generalized across multiple fields creates theory and knowledge.

JIK welcomes papers on innovations that improve the quality of knowledge or that can be used to develop knowledge. Innovation is a broad concept, covering innovation processes, structures, outcomes, antecedents, and behaviors at the organizational level in the private and public sectors as well as at the individual, national, and professional levels.

JIK articles explore knowledge-related changes that introduce or encourage innovation to promote best practices within society. JIK provides an outlet for high-quality studies that have undergone double-blind peer review. In doing so, JIK ensures that such studies reach a global readership of scholars, consultants, practitioners, international leaders, and policymakers who recognize the importance of innovation and knowledge as economic drivers and who base their decisions on new ideas and findings in innovation and knowledge.

JIK publishes content in the form of theoretical articles, empirical studies employing quantitative or qualitative methods, practice-oriented papers, teaching-oriented papers, case studies, book reviews, conference reports, short articles on current trends in science and society, abstracts of recent innovation and knowledge PhDs, and shorter opinion-based and review articles, commentaries, and debates.

JIK publishes state-of-the-art research on emerging topics in the world of innovation and knowledge and appeals to a broad readership. The editors welcome suggestions for special issue topics. JIK articles should demonstrate contextual differences, while highlighting lessons for the wider audience. In sum, JIK is an interdisciplinary journal devoted to advancing theoretical and practical innovations and knowledge in a range of fields, including Economics, Business and Management, Engineering, Science, and Education.

JIK has a broad scope to the following areas: 1. Innovation including but not limited to: open innovation, innovation adoption and diffusion, organizational behavior and innovation, creativity, improvisation, and individual innovation, innovation in teams and groups, institutional and social innovation, consequences of innovation, critical approaches to innovation or innovation alliances and networks in relation to knowledge, and vice versa.

Knowledge patterns in relation to innovation. Knowledge-related changes that introduce innovations and best practices in society. Globalization in innovation and knowledge. Innovation policies and practices that lead to knowledge.

Cross-cultural case studies in knowledge and innovation. New practical models and paradigms for understanding and fostering innovation and knowledge.

Knowledge and innovation derived from data. Information systems in knowledge and innovation. Knowledge and innovation in organizations and their behaviors. Knowledge- and innovation-based systems, products, and processes. Issues that affect the developers of education systems and educators who implement and manage innovations and knowledge. Ethics in knowledge and innovation. Knowledge and innovation transfer. Quality in knowledge and innovation. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.

SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Despite inter-clustering being an important specific form of inter-organizational network, it has rarely been investigated. These cases give some interesting insights into these issues. With interviews applied to the executive directors of the selected clusters, together with documentary analysis, the empirical evidence obtained lets us conclude that inter-clustering is seen as a network promoting the share of knowledge and learning among the actors involved, and allowing improvement in the activity carried out, the product or service provided, at both the firm and regional level.

Moreover, we extend the existing literature on knowledge management, organizational learning and inter-clustering. Inter-clustering relations also offer also a new framework to analyze a network of knowledge and learning that has seldom been studied..

Whereas the industrial economy valued vertical integration, the knowledge economy stimulates and is stimulated by the formation of inter-organizational relationships and business arrangements constructed in a network. In this context, according to Sohn , the importance of clusters is highlighted as a type of inter-organizational network that contributes to regional development and competitiveness. This author and Cusin and Loubaresse also mention the relevance of studies on industrial clusters operating as an inter-organizational network, and how they are associated with regional development and competitiveness.

Here, competitiveness moves from a one-directional, individual and endogenous process in the business domain to become an open, multi-directional, collaborative and network process.

TerWal and Boschma argue that industrial clusters are networks of a social nature and include different stakeholders who interact, evolve and contribute to performance in a specific geographical context. According to Ahuja, Soda, and Zaheer , the origins and dynamics of network structure warrant additional research since despite existing studies about endogenous mechanisms that lead to network development e.

Calantone, Cavusgi, and Zhao and Kay et al. These researchers also underline that many aspects related to the dynamics of network formation require deeper study. In these circumstances, clusters become important as a form of inter-organizational network that can contribute to regional development and competitiveness Sohn, For Cusin and Loubaresse , from this perspective, inter-clustering is a synonym for cooperation.

More precisely, the aim is to assess top management's perception in six Portuguese clusters located in the same or a nearby geographical area, distinguished by the ECEI European ClusterExcellence Initiative as Gold Label. The following questions were also defined for the purpose of this study: Q1: How do inter-clustering linkages permit the knowledge-sharing and learning processes?

Q2: What are the challenges for inter-clustering representing a competitive advantage at the individual person-based and trans-regional levels? Q3: How does inter-clustering promote regional development and competitiveness? Therefore, our contributions are twofold.

First, inter-cluster relations offer a new framework. We show inter-clustering as people-based relationships across clusters Saxenian, These types of networks are designed by and systematically involve cluster-level actors. Second, we discuss how these networks can be seen as an instrument to share knowledge and a learning process, as well as showing the motivation for forming inter-cluster networks.

Finally, we believe that this study constitutes an interesting and innovative line of research, especially when we look into knowledge transfer and learning in relations among close clusters. Our paper also highlights the importance of inter-cluster cooperation to promote regional development and competitiveness.

We proceed as follows. First, we outline the theory of clusters and the inter-cluster phenomenon. Second, we show how inter-cluster networks can be a way to share knowledge and learning. Thirdly, we present our research methodology and based on our findings, we specify and compare six Portuguese clusters.

Finally, we outline the main conclusions and the implications of our results. Nevertheless, according to Felzensztein, Stringer, Benson-Rea, and Freeman , researchers do not have a single definition of cluster.

For Porter , although clusters are formed on any geographical scale, they are mainly localized and related organizations. Porter , states that clusters are geographical concentrations of firms and institutions interlinked in a given area or specific sector of activity, including industries and other essential entities for competitiveness. Clusters are characterized as cooperation and collaboration networks that provide significant opportunities to stimulate economic development and strengthen competitiveness Porter, According to Zvyagina , the cluster typology can also be complemented by the effects of inter-cluster interaction.

This effect is shown in the fact that clusters, as a whole or individually organizations and firms , can interact with other types of clusters. This interaction can lead to the creation of new competitive products, fundamentally due to the synergetic effect Fig.

The greatest potential of inter-cluster interaction is associated with educational and infrastructural clusters, to a certain extent, with the capacity to carry out functions of interest to any type of cluster.

Note : a Inter-organizational collaboration; b inter-cluster interaction. Source : Adapted from Omelyanenko According to Anatoliyovych, in a knowledge-based economy, clusters of innovative firms emerge close to sources of knowledge. They are based on sophisticated infrastructure, where knowledge is created, developed, shared and exchanged. Clusters are characterized by highly concentrated and effective links between business-people, investors and researchers.

Clusters can take on a variety of forms, depending on their main technological and commercial areas of specialization. In most cases, they operate in localized geographical areas and interact in larger innovation systems at the regional, national and international level. With globalization, clusters have become more dynamic and are key factors in a country's capacity to attract international investment, which generates new technological knowledge Kay et al.

Clusters are of interest to investors in innovation risk capital, etc. It is also considered essential to create extended and improved conditions for innovation in the intra and inter-firm domains, to allow the insertion in international markets of ranges of differentiated products and services with greater added value.

Source : Portuguese Innovation Society — 20 years They are frequently supported by national or regional policies Dohse, In these cases, local firms created bridges of cooperation with leading firms located outside the cluster in order to incorporate new competitive advantages Rabellotti, In this connection, according to Morrison and Rabellotti and Kay et al.

The authors found that knowledge flows in a given sector are restricted to a strongly related local economy e. Boschma mentions that too much clustering or network closure can harm the dynamics of local learning and that larger, more successful producers in the local sphere are not interested in forming internal knowledge links with local, small and medium-sized enterprises SME.

Regarding network formation, larger firms are found to prefer to remain on the periphery of the knowledge network and strengthen their links to sources of knowledge outside the cluster, whereas smaller firms are closely inter-linked and communicate with external sources of knowledge.

The emergence of knowledge within and over the different ontological levels can be stimulated through interaction communities or contexts. Accordingly, a team, organization or inter-organizational network represents contexts or communities of interaction favoring the creation of support platforms for their members for the articulation, share and amplification of individual perspectives and ideas, as well as to build shared understanding, i.

Regarding the perspective of knowledge as an input and output resource, this originates in the resource-based theory of the firm Wernerfelt, Through efficient and effective management of a set of specific and strategic resources, as well as their respective returns, organizations have the potential to create strategic and competitive differentiation.

In this context, and according to Balestrin and Verschoore , inter-cluster networks have the capacity to facilitate joint actions and resource transaction to achieve organizational objectives. Inter-cluster networks are therefore a phenomenon in organizational theory, and have consequently been much studied from different theoretical viewpoints.

This inter-disciplinary nature of contributions was also shown by Oliver and Ebers and Gnyawali and Madhavan when presenting the main theoretical streams used in research about cooperation networks between organizations, highlighting: industrial economy, resource-dependence approach, social network theory, critical theories, institutional theory, transaction cost theory and the organizational strategies approach. When two or more clusters have common and complementary characteristics and areas e.

In this context, it is underlined that although competitive interdependence may be dominant or is potentially more probable between clusters operating in the same sector of activity, relationships of cooperative interdependence can exist between clusters of the same or different sectors of activity, involving or not organizations that compete with each other. According to the authors, local and personal knowledge i.

Carrier reefer oil capacity

Evelien T. Berends, Annemarie Kuipers, Marietta M. Ravesloot, Rolf T. Urbanus, Suzan H. The complement and coagulation systems are two related protein cascades in plasma that serve important roles in host defense and hemostasis, respectively. Complement activation on bacteria supports cellular immune responses and leads to direct killing of bacteria via assembly of the Membrane Attack Complex MAC. Recent studies have indicated that the coagulation system also contributes to mammalian innate defense since coagulation factors can entrap bacteria inside clots and generate small antibacterial peptides.

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The Journal of Innovation and Knowledge JIK focuses on how we gain knowledge through innovation and how knowledge encourages new forms of innovation. Not all innovation leads to knowledge. Only enduring innovation that can be generalized across multiple fields creates theory and knowledge. JIK welcomes papers on innovations that improve the quality of knowledge or that can be used to develop knowledge. Innovation is a broad concept, covering innovation processes, structures, outcomes, antecedents, and behaviors at the organizational level in the private and public sectors as well as at the individual, national, and professional levels. JIK articles explore knowledge-related changes that introduce or encourage innovation to promote best practices within society. JIK provides an outlet for high-quality studies that have undergone double-blind peer review.

Jeffrey J. Wine

Both models use similar chassis and share the high-gloss piano-black cosmetics of the line. Ever since Keroes and Hafler popularized the ultra-linear UL connection of the push-pull output stage in the early s, pure pentode designs seem to have fallen off the map. Some of the most popular and highly respected power amps of all time used the UL connection. Even the McIntosh unity-coupled output stage can be considered a variation on the UL theme. Pentode designs have been castigated in the past for their poor damping factors pentode boom and susceptibility to load interactions.

Vincent Audio SA-31MK Hybrid Linestage Preamplifier & SP-331MK Hybrid Power Amplifier (TAS 208)

To gauge your status, take The Audiophilia Nervosa Test at audiophilia. To be sure, there are many fine examples of value-oriented gear out there. For guys like that, like me, my suggestion is to stop chasing the Holy Grail, pour a shot of single malt a relatively affordable indulgence , sit back, and enjoy the music. Which is something, I can report, that the newest gear from Vincent Audio allows for quite handily. The SAMK linestage preamp and SPMK power amplifier are both hybrid designs, aiming to marry the reliability, speed, and power of solid-state with the warmth, air, and harmonic richness of tubes.

Apple’s warranty advertising comes under EU’s microscope

Remember me. Parking wars gina bova. Above, Pier 41, home to Red Hook Winery. Outside, Meadow burns rubber trying to get into a parking space and then runs across a street against the light as cars whiz by her. In an earlier piece FAIR. This west coast Housewife needs her benefactor. Featuring the faculty performing hands-on demonstrations of the skills and techniques they teach. To view a high quality image.

TESCOMA 654006 CLASSIC SALT & PEPPER SET (LIQUIDATION)

European scrutiny of Apple's warranty policies is on the rise. On Monday, Viviane Reding, the European Union's Justice Commissioner, wrote a letter to the EU's 27 members requesting they review whether Apple has properly advertised buyers' rights to a two-year warranty on their products. If the countries find that Apple hasn't given sufficient warranty information to consumers, the company could face additional fines for misleading advertising.

Audio Reviews by Year

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Geneticist Professor Rodney Scott and computer scientist Professor Pablo Moscato come from disparate academic backgrounds, but they share a common purpose. The leading researchers are blending their respective knowledge with the aim of making personalised medicine a reality. As one of only two research sites in Australia that directly link bioinformatics with clinical research practice, it is at the forefront of the emerging field of developing patient-tailored treatments based on genetic analysis. Both researchers bring considerable expertise to the collaboration. Scott has been working in the field of hereditary diseases for 20 years, and has attracted global recognition for his genetic research, particularly in the areas of breast and bowel cancers. Moscato began his influential work in computer science in the late s as a member of the Caltech parallel computing group — supercomputing pioneers based at the California Institute of Technology.

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News, tours, venues, and more! Stay up to date with Meyer Sound. New Hires in Education, Tech Services, and Sales November 10, Meyer Sound has announced the filling of six positions spanning education and training, sales management, and technical services, with new hires based in the USA, the Middle East, and China. Montreux Jazz Festival China November 3, Hangzhou, China is more than 9, kilometers from the shores of Lake Geneva, yet for four days in October the first Montreux Jazz Festival China successfully bridged both distance and cultural differences with the universal language of music. Also, to ensure the same sonic excellence experienced for 35 years on the shores of Lake Geneva, Montreux Jazz Festival China collaborated with Meyer Sound to ensure the best quality sound. Along with strict vaccination requirements, the unprecedented all-outdoor format promoted health and safety for artists and audiences alike.

Electric lighting. Cosmetics, soap, etc. Consulting in Financial Services and assisting regulated companies to be in compliance with all the laws, rules, regulations, codes or guidelines that are applicable to them. Import and distribution of fine wine, champagne and spirits.