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On behalf of the faculty, students, and staff of Virginia Commonwealth University, I extend to all of you a warmest welcome to out fourteenth celebration of the Cabell First Novelist Reward. I have a special greeting tonight for our Honors students. In order to earn a credit that we get free. Starting in the fall of , next year, we will be able to provide a much better and more permanent home for the Cabell First Novelist Ceremony in our soon to be completed new library building right here on the corner. I hope some of you have been in there. We have a lot left to do the state funds just will not support.

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• A mum was rushed to hospital after a cartilage piercing turned her face BLUE
• Headache: cortical vein thrombosis and response to anticoagulation
• Boris Johnson to get ‘safe and effective' Oxford/AstraZeneca vaccine
• Portal Vein Tumor Thrombus in the Presence of Locally Advanced Hepatocellular Carcinoma
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• Boris Announce High-Res Digital Reissues of Vein, Präparat, and Eternity
• Tectonics and Metallogeny of East Kazakhstan
• Boris Celebrates 25 Years By Cleaving The Earth In Two With 'Absolutego'

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A mum was rushed to hospital after a cartilage piercing turned her face BLUE

Metrics details. In patients undergoing major liver resection, portal vein embolization PVE has been widely used to induce hypertrophy of the non-embolized liver in order to prevent post-hepatectomy liver failure. PVE is a safe and effective procedure, but does not always lead to sufficient hypertrophy of the future liver remnant FLR.

We have developed the so-called liver venous deprivation LVD , a combination of PVE and HVE during the same intervention, to optimize the phase of liver preparation before surgery.

Secondary objectives are assessment of tolerance, post-operative morbidity and mortality, post-hepatectomy liver failure, rate of non-respectability due to insufficient FLR or tumor progression, per-operative difficulties, blood loss, R0 resection rate, post-operative liver volume and overall survival. Objectives of translational research studies are evaluation of pre- and post-operative liver function and determination of biomarkers predictive of liver hypertrophy.

This study was registered on clinicaltrials. Peer Review reports. In patients undergoing major liver resection, portal vein embolization PVE has been widely used to induce hypertrophy of the non-embolized liver in order to prevent small-for-size and post-hepatectomy liver failure. PVE is a safe and effective procedure, but does not always lead to sufficient hypertrophy of the future liver remnant FLR [ 1 ].

Therefore, several approaches have been proposed to improve PVE:. Recently, the ALPPS associating liver partition and portal vein ligation for staged hepatectomy procedure has been developed by surgeons.

Although a very high rate of liver hypertrophy has been reported [ 2 ], ALPPS was demonstrated to tremendously increase perioperative mortality and morbidity [ 3 ]. To optimize the phase of liver preparation before surgery, we developed the so-called liver venous deprivation LVD technique, a combination of PVE and HVE during the same intervention.

More recently, we showed that LVD could provide marked and very rapid increase not only in FLR volume but also in FLR function [ 6 , 7 ] assessed with 99m Tc mebrofenin hepatobiliary scintigraphy with SPECT which has been validated as a quantitative method for evaluating liver function [ 8 ].

Secondary objectives are listed in Table 1. Translational research objectives are i evaluation of pre- and post-operative liver function and ii determination of biomarkers predictive of liver hypertrophy. Our hypotheses for sample size calculation are based on a systematic review on PVE before liver resection, involving patients [ 9 ]: the mean increase of the FLR volume was In our preliminary study [ 5 ] and in a more recent paper by Le Roy et al.

Finally, planned enrollment will be 64 subjects. Liver metastases considered as resectable from colo-rectal origin as validated by a multidisciplinary committee with at least one senior hepatic surgeon. Serious non-stabilized disease, active uncontrolled infection or other serious underlying disorder likely to prevent the patient from receiving the treatment. Contraindication to MRI in the following cases, a CT-scan must be used instead : Pacemaker or neurosensorial stimulator or implantable defibrillator, cochlear implant, ferromagnetic foreign body.

Impossibility to sign the informed consent document or to adhere to the medical follow-up of the trial for geographical, social or psychological reasons. Figure 1 summarizes the design of the study. Secondary endpoints are listed in Table 2.

Endpoints for the translational research are:. Evaluation of pre- and post-operative liver function. The biological studies on the samples will be managed by a biological committee and funded separately. The portal system will be accessed using a micropuncture set either through the left or through the right portal vessels.

Portal pressure will be measured. If right hemihepatectomy is scheduled: Right hepatic vein as well as accessory right hepatic vein s when present are accessed using a micropuncture set. After opacification, a 0. Then, the portal system will be accessed using a micropuncture set either through the left or through the right portal vessels. After PVE is completed, microguidewire s left in hepatic veins are used to introduce a Neff set.

Through the Neff set, a 0. After plug deployment, opacification is performed through the sheaths to check for plug occlusion and potential veno-venous collaterals. At last, tract embolization is performed using the same mixture. Tract embolization of portal vein access is performed using the mixture used for PVE.

Pain medication is administered following the recommendations of each center. Morphine administration is allowed. Hepatic vein s are accessed under US guidance using micropuncture sets and embolized using Amplatzer vascular plug s and cyanoacrylate for distal branches and veno-venous collaterals. This will bring additional useful data given the great potential of liver function to become a more accurate predictor of post-operative liver dysfunction than liver volume.

In conclusion, we believe that LVD is a promising method to improve liver preparation before major hepatectomy, thereby increasing the number of patients undergoing curative surgery and preventing drop-out due to tumor progression. This prospective, multicenter and randomized phase II trial is mandatory to confirm our preliminary results.

Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review. World J Surg. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings.

Ann Surg. Article Google Scholar. Sequential preoperative ipsilateral hepatic vein embolization after portal vein embolization to induce further liver regeneration in patients with hepatobiliary malignancy. Simultaneous trans-hepatic portal and hepatic vein embolization before major hepatectomy: the liver venous deprivation technique.

Eur Radiol. Extended liver venous deprivation before major hepatectomy induces marked and very rapid increase in future liver remnant function. Liver venous deprivation versus portal vein embolization before major hepatectomy: future liver remnant volumetric and functional changes.

Hepatobiliary Surg Nutr. J Nucl Med. Portal vein embolization before liver resection: a systematic review. Cardiovasc Intervent Radiol. Combined preoperative portal and hepatic vein embolization Biembolization to improve liver regeneration before major liver resection: a preliminary report.

Perioperative impact of liver venous deprivation compared with portal venous embolization in patients undergoing right hepatectomy: preliminary results from the pioneer center. Preoperative portal vein embolization alone with biliary drainage compared to a combination of simultaneous portal vein, right hepatic vein embolization and biliary drainage in Klatskin tumor. Download references. The authors declare that they have no competing interests relative to this study.

The National Institute of Cancer was not involved in the design of the study and collection, analysis, interpretation of data and in writing the manuscript. You can also search for this author in PubMed Google Scholar. All authors will be involved in the conduct of the clinical trial.

All authors read and approved the final manuscript. Correspondence to Boris Guiu. All patients will give their written informed consent before any study-related assessment start. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and Permissions. Deshayes, E. Study protocol of the HYPER-LIV01 trial: a multicenter phase II, prospective and randomized study comparing simultaneous portal and hepatic vein embolization to portal vein embolization for hypertrophy of the future liver remnant before major hepatectomy for colo-rectal liver metastases.

BMC Cancer 20, Download citation. Received : 30 April Accepted : 12 June Published : 19 June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background In patients undergoing major liver resection, portal vein embolization PVE has been widely used to induce hypertrophy of the non-embolized liver in order to prevent post-hepatectomy liver failure.

Trial registration This study was registered on clinicaltrials. Background In patients undergoing major liver resection, portal vein embolization PVE has been widely used to induce hypertrophy of the non-embolized liver in order to prevent small-for-size and post-hepatectomy liver failure.

Therefore, several approaches have been proposed to improve PVE: i. Full size image. Availability of data and materials Not applicable. References 1. Article Google Scholar 3. Article Google Scholar 4. Article Google Scholar 5. Article Google Scholar 6. Article Google Scholar 9.

Headache: cortical vein thrombosis and response to anticoagulation

S Vaccination, March 2 to April 21, Question What were the clinical characteristics of the first US patients reported to have cerebral venous sinus thrombosis CVST with thrombocytopenia following receipt of the Ad Findings In this case series of 12 patients, all were women, younger than 60 years, and had symptom onset ranging from 6 to 15 days after vaccination requiring hospitalization. Of 11 patients with heparin-platelet factor 4 enzyme-linked immunosorbent assay ELISA heparin-induced thrombocytopenia HIT antibody test results, all were positive. Meaning This case series may inform clinical guidance and investigations into the potential relationship between the Ad

Boris Johnson to get ‘safe and effective' Oxford/AstraZeneca vaccine

By Jessica Summers For Mailonline. A mother-of-one was rushed to hospital when her face turned blue after she got her ear pierced. Courtney Taylor, from Leeds, was left in agony after her cheek started swelling up. The year-old got her tragus - the small pointed cartilage in front of the concha - pierced on both ears. While the right side was fine, the left side of her face becamse painful and it was too sensitive to clean the piercing. Courtney was reassured by the piercer at the salon she went to that it was fine, but then her face turned blue and pals warned her it could be killer condition sepsis. They were eventually able to rule out life-threatening blood poisoning but said the piercing was too close to her face and a vein and possibly a nerve had been nicked. Courtney Taylor was left in pain and feeling confused after an ear piercing turned her face blue. The blue mark spread across her face by the piercing site and continued to spread down her neck. The young mum went to hospital after friends warned her it could be sepsis.

Portal Vein Tumor Thrombus in the Presence of Locally Advanced Hepatocellular Carcinoma

A surgical instrument for treatment of superficial varicose veins in a body is provided. The surgical instrument includes at least one vein-engaging element disposed within or on a housing being adapted for insertion into a tissue. The at least one vein-engaging element is operable to a vein-engaging state whereby it protrudes from the housing at a length thereof. A surgical instrument adapted to engage superficial varicose veins in a body from outside of the veins, comprising: a handle;an elongated housing attached to the handle; andan elongated vein-engaging element disposed within the housing, the vein-engaging element comprising a plurality of teeth arranged along a length of the vein-engaging element;said elongated vein-engaging element being operable to a vein-engaging state in which said plurality of teeth protrude from said housing along most of a length of said housing,wherein said housing includes at

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You can enlarge or reduce the browser window. Press CTRL and 0 to reset your browser window to normal size. Artificial cardiac valves for children typically come from animals and need to be replaced every few years. Pediatrician Dr. Boris Schmitt has developed exactly such biological cardiac valves from the pericardium, the heart sac.

Boris Announce High-Res Digital Reissues of Vein, Präparat, and Eternity

David C. Madoff, Bruno C. Odisio , Erik Schadde, Ron C. Gaba, Roelof J. Bennink, Thomas M.

Tectonics and Metallogeny of East Kazakhstan

Boris formed during the early '90s and consisted of guitarist Wata, bassist Takeshi, vocalist Atsuo, and drummer Nagata who left the group in , leaving the group as a trio with Atsuo handling both drums and vocals. They made their first recorded appearance on an obscure compilation entitled Take Care of Scabbard Fish, released only in Japan and now out of print. Absolutego, their full-length debut, came out in on the band's own Fangs Anal Satan imprint but was unavailable in the U. Their next album, Amplifier Worship, came out on the Mangrove label in and was also unavailable in the U.

Boris Celebrates 25 Years By Cleaving The Earth In Two With 'Absolutego'

RELATED VIDEO: Boris - Vein -Noise- (Full Album)

A Royal Navy warship was "sticking up for our values" in an incident with Russian forces in disputed waters around Crimea, Boris Johnson has said. The prime minister said the UK does not recognise Russia's annexation of Crimea and was pursuing freedom of navigation in international waters. Mr Johnson denied UK relations with Russia were at an all-time low. He refused to be drawn on whether he had personally authorised the HMS Defender voyage.

Starting out, big band leaders. The performance presaged an anticipated return to the road in , where Mellencamp wishes to play theaters as opposed to arenas and amphitheaters. This summer, Mellencamp also released The Good Samaritan Tour live album and documentary, chronicling the trek that saw him playing free shows in public parks and common spaces across the U. Bryan Rolli Published: December 13, Share on Facebook Share on Twitter.

Chilled by a cocktail of tube-fed drugs, it grew weaker and beat more slowly until the spikes on the electronic heart monitor flattened to a horizontal line. Renat Akchurin took the future of this volatile country into his skilled hands. Here is a look at what ailed the Russian president, what was done to fix it and what dangers he still faces in recovery. This constriction led to myocardial ischemia, an inadequate supply of blood and oxygen to the heart muscle.