Giacomo dapolito speaker
A "Blunt Withdrawal"? Alexander, John O. Hayward, and David Missirian. Begone, Euclid! Kolluri, and Pan Zhen.
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Some of the images in this book has been published in scientific papers: Fig. I personally believe that it is impossible to choose a path of research while not following at the same time different others: a research is made out of different paths interweaved together.
Thus, I cannot help but notice my satisfaction in observing such an important and great scientific platform as San Raffaele is.
Such platform includes the basic research, the translational research and the clinic and applied researches into a joined unity. Dear Raffaelians, Physicians, Researchers, and all Personnel You all, who here in Italy and in our San Raffaele centres abroad form a true Army to fight illness and death, which were never sought after by God. God, that is, who created man in a condition of full strength, apt for a perfectly healthy life.
You are in charge of searching for the adequate biological, environmental, and ethical conditions to carry man back to his original state of perfection, as a king-owner of the Generating Universe, with the duty of ruling it and mastering it [possidete eam].
Do not surrender to difficulties. Your self-awareness - which is to say, your awareness of the human value which resides in each one of us leads us to responsibility, prudence, and, at the same time, to the requisite resilience and audaciousness.
Sono convinto da sempre che non ci sia cura senza ricerca. Vi penso e Vi amo tutti. To achieve this objective, we want to perform cutting-edge science and to advance the knowledge of human diseases resulting in the identification of novel therapies. Our vision is that Research is the backbone of the SRSI, intersecting and connecting with both the clinical and the teaching programs. Our objective is to further integrate research, teaching and clinical activities by aligning preclinical and clinical research with our clinical strengths.
The initial areas of research covered by Di. This status was renewed in , following an audit by the Ministery of Health. In the construction Di. This allowed the much needed growth of the University and will create additional space for SRSI research groups, with dedicated space for new state-of-the-art technology platforms, and expansion of our translational research efforts in key disease areas such as regenerative medicine, neuroscience, immunology, inflammation, cardiovascular and oncology.
In the last two years a new research strategy and research organization has been implemented, building on current strengths to invest in new strategic areas in order to further increase our competitiveness as a center of excellence in biomedical research and to create the best environment for the translation of fundamental research into clinical applications. Together with the implementation of this new research organization, the administrative and supporting research structure has also been extensively reorganized see introduction by Maurizio Savi, the Chief Operating Officer for research.
T 1 and Di. T 2 and people, including physicians, research nurses, residents and clinical fellows, on clinical research projects in the hospital. The research conducted in these areas has the common goal to increase knowledge on the molecular basis of diseases and to identify innovative therapies and new diagnostic options.
The main objectives of HSR-DRI are to identify and apply novel treatments to prevent islet beta cell destruction and to restore sufficient insulin production in type-1 diabetes patients Furthermore, the SRSI hosts several scientists belonging to the Dulbecco-Telethon Institute DTI , which sponsors research on the molecular and biological mechanisms of gene regulation and genetic diseases. Research activities within Research Divisions and Centers are at the intersection of clinical activities, which are organized in 12 Clinical Departments see introduction by Renato Botti, General Director of the clinical area.
In this classical matrix model the Research Divisions intersect with many Clinical Departments in which basic research units BRU and clinical research units CRU are fully integrated and aligned. Matrix of research activities in the research Divisions and Centers integrated with the Clinical Departments.
The following five research divisions: Molecular Oncology; Neuroscience; Regenerative Medicine Stem Cells and Gene Therapy; Immunology Transplantation and Infectious Diseases; Genetics and Cell Biology became fully operational, whereas operational establishment of the Research Division in Metabolic and Cardiovascular Science is progressing well and will be completed by the end of The Research Center for Genomics, Bioinformatics and Biostatistics and the Research Center for Imaging were all started in with the aim to meet the increasing need for state-of-the-art imaging and functional genomic technologies.
A new director for the Center for imaging was appointed. These two technology platforms will support all pathological and therapeutic areas and are expected to further favor integration between basic and clinical research and to provide strong impulses for translational research from bench to bed-side and back again. The Research Programs are aimed at creating synergies between groups with different expertise and defining common strategic investments, which will favor fast-track translational research.
Currently, the overall five-year strategic plan has been completed and will be presented to our International Scientific Advisory Board. The Advisory Board was appointed by the Board of Directors of the San Raffaele Foundation and has the primary function to assist the Board in the evaluation of the quality of our research, our research strategies and implementation plans in keeping with the highest international research standards. Despite the worldwide financial and economical crisis of , which also had an impact on our research organization, a number of initiatives were successfully carried out: - The first among the three new research buildings of Di.
T 2 was equipped and is now fully occupied. In addition, the new space allowed the expansion of our cytofluorimetry and FACS sorting facility.
We believe this is a key achievement in the integration of clinical, teaching and research activities as these professionals will be at the interface that allows optimal communication and interaction between the three areas.
The aim of this project is to define the career path for young investigators, allowing them more independence and recognition with more responsibility and accountability and to establish transparent and well-defined criteria for periodical evaluations of the performance of our scientists. The total number of scientific publications was , with a total Impact Factor of Based on these results, our Institution is the most highly ranked Italian IRCCS in terms of scientific level and scientific productivity figures 2 and 3.
Figure 2. Submission of these clinical trial protocols were supported and guided by the Clinical Research Office. Figure 4. The high level of innovative research in the SRSI is also reflected in the issue of 96 patents and 38 patent families, while 52 licenses were taken out by external parties. The impressive critical mass and quality of our scientific community was highlighted during our yearly scientific retreat, which in was again organized in Stresa with three full days of scientific presentations given by basic and clinical scientists.
Finally, in a number of important educational initiatives, scientific events and prestigious international meetings were organized and hosted by our basic and clinical scientists. A special mention should go to the scientific symposium organized in honour of Professor Guido Pozza who was the scientific director of the SRSI for 15 years and who continues to be a highly experienced mentor and advisor to our scientists.
The new space will be used to further optimize current key research activities, such as stem cell and gene therapy, and to accommodate research groups working in new strategic areas, such as molecular oncology, translational genomics and preclinical imaging.
The SRSI will continue to be a multidisciplinary Institute, but we will also pay particular attention to invest in research on those diseases with a high unmet medical need and in therapeutic areas of increasing medical demand, such as oncology and cardiovascular research. The main efforts in will be devoted to a new project aimed at integrating clinical, teaching and research activities in the area of oncology. This new initiative in cancer research and therapy will be built on all the know-how, expertise and resources already present at the SRSI.
In addition, we plan to establish a strong and fully operational Metabolic and Cardiovascular Diseases Research Division. Investments in basic research in this latter increasingly important area, in which the SRSI has proven clinical excellence, will significantly increase our visibility and competitiveness.
We will continue to strengthen our position as a leading center for translational medicine by giving rise to a Clinical Research Center. In this context, close collaboration between basic researchers, clinical investigators and physician scientists will be strongly supported with the ultimate goal to apply new therapeutic principles, invented at the laboratory benches, as efficiently as possible to our patients.
In particular, we are aiming towards expertise in the fields of wide genomic analyses of complex diseases, stratification of patients by genotyping and phenotyping, pharmacokinetics and pharmacogenomics, besides becoming an active Center for the clinical proof of concept trials.
I am also convinced that it will make us attractive for young Italian scientists who currently work abroad, but are highly motivated to return home and contribute to the international competitiveness of Italian medical science. The worldwide financial and economical crisis is not yet over and will also be a year of constraints, which will be a challenge for the speed of implementation of our strategic research plan.
However, nothing will stop us continuing with the integration of high quality basic and clinical research by devoting dedicated investments to new translational research units.
I also would like to express my gratitude to the project and group leaders and all members of the scientific community for their continuous support and sense of responsibility in this difficult year. Finally, a special thank you goes to all scientists, physicians, staff, post-doctoral fellows and students who, through their work, efforts, enthusiasm and passion, contributed to the research progress illustrated in this scientific report and who make the SRSI such a wonderful place to work at.
With this in mind, the organizational-management structure of the Research Area has developed and implemented a shared and integrated governance and management system, both of the structures and processes of the core business i.
Our priority for the future will be to define, according to the objectives highlighted in the Strategic Scientific Plan, a strategic-operational plan with which to steer all research area activities towards the same goals, and to control particularly critical development areas, such as fundraising, and creation of value for research and comunication.
It is highly desirable for a mission-oriented non-profit Institution such as ours that this strategic-operational plan is on one hand oriented towards communication, and on the other, I would say above all, it aims to provide an efficient level of organizational governance, functional to the monitoring and strengthening of the relationships with our stakeholders, internal and external.
If conceived in this way, this plan will be able to produce noticeable and beneficial effects on the research organization in terms of alignment with and valorization of its mission.
Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, doubleblind, placebo-controlled phase IIb study. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. It is relentlessly pursuing its three interrelated activities of clinical care, research and education since , when it was established, and represented one of the first examples of a fully independent private hospital in Italy.
Originally specialized in diabetes and metabolic diseases, the status of research hospital was confirmed for the area of Molecular Medicine in the years and Its high quality medical assistance and the availability of an extensive area of about In the hSR activity counts The Hospital counts about 3. In January , after the approval by the Board of Directors, the Hospital started to organize the medical areas in Clinical Departments.
Due to the complexity of the Institution, this process required a great effort for the analysis and definition of aggregation area, operational procedures and for the definition of the activity indicators.
The process is still ongoing, but almost completed. From December to January , Arrithmology Department has been absorbed by Cardio-ThoracicVascular Department, generating a total Departments reduction from 12 to Imaging Radiology, Neuroradiology, Nuclear Medicine 3.
Rehabilitation Neurological, Cardiovascular, Orthopaedic 5. The objective of the creation of these areas is to promote standardization of activities, to realize common projects and synergies, to encourage the interexchange of the human and technological resources, to promote the communication between the Departments. All the procedures and processes were discussed and approved jointly, deriving from the common objective to increase the quality of the medical treatments and the efficiency of the Institute.
The project management has been played and is played by the Health Direction, supported by the commitments of Board of Directors and General Direction. Each Director has been assigned several measurable objectives included in the so-called Cruscotto Dipartimentale.
The Cruscotto Dipartimentale is aimed to monitor yearly the reaching of the goals assigned and the proper enforcement of the Department processes. The Departmental Director is assisted by a Director Management Assistant DMA , a person with management background, with the function to co-ordinate the Department as far as the administrative issues are concerned and to facilitate the relationships between the Department and the hSR Health Direction and the Institute management.
The Departmental Director is also supported by a so- called Department Area Coordinator DAC that performs clinical activity and, in addition, is responsible for the coordination and the management of a specific Departmental Area of activity i. Research, Information Technology, Quality…. The implementation Departmental Model of the San Raffaele hospital is progressively reaching its goals with regard to economic efficiency and clinical effectiveness maintaining the central role of the patient through the full integration and the co-sharing of the human, technologic and logistic resources.
Biochemistry and Genetics, Dept. The tenet of this aim is that any significant progress toward the cure of cancer can only be based on an improved understanding of its pathogenesis, which, in turn, will lead to the development of improved diagnostics and more rationale therapeutic interventions. This will be achieved by fostering extensive collaborations between basic scientists and clinicians. The Personnel is close to people.
The Lab space allocated to the Division is about m2 Goals - The main goal is to join efforts with the Clinical Department of Oncology to create an internationally competitive Integrated Cancer Center HSR-ICC which integrates cancer research, treatment and education with the aim of curing cancer. Two major areas of excellence have been identified: Cancer Microenvironment; and Cancer Immunology and Immunotherapy. We are exploring the possibility of developing additional scientific programs.
Its investigations exploit the role of the immune system and of its manipulation in specific cancers, especially melanoma and epithelial cancers. The program spans from genomic and epigenomic studies to the characterization of the interactions between genes and microenvironment in the development and progression of blood cancers.
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Programma - Scuola di Medicina
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HSR-TIGET - Ospedale San Raffaele
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Keywords: The Szasz-Mirakjan-Kantorovich operators , statistical convergence , modulus of continuity , Peeters K-functional , weighted modulus of continuity. Authors: Bianca A. Szasz , Keiichi Okuyama.
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