Ampk pathway communications
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- European Journal of Science and Technology
- AMP-activated protein kinase pathway and bone metabolism
- AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
- Metformin targets multiple signaling pathways in cancer
- Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
- Take a look at the Recent articles
- Targeting AMPK for cancer prevention and treatment
- AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
- AMP-activated protein kinase
European Journal of Science and Technology
It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U. Department of Agriculture field libraries. In fiscal year Oct through Sept NAL delivered more than million direct customer service transactions.
Data provider:. National Agricultural Library. Active Data provider submitted metadata in the last calendar year. Journal Article. Access the full text Link Link. Lookup at Google Scholar. Non-alcoholic fatty liver disease NAFLD , a hepatic manifestation of metabolic disease, is an important complication of diabetes mellitus DM. Moreover, the pathological formation of NAFLD is closely related to accumulation and polarization of hepatic macrophages.
Saxagliptin, a newly antidiabetic agent, can suppress hepatic inflammation reportedly. However, underlying mechanisms remain poorly explored. In this study, we showed saxagliptin alleviated lipid accumulation and attenuated liver inflammation with downregulation of inflammation factors in diabetic rats.
From the journal. Biochemical and biophysical research communications. Bibliographic information. All titles:.
AMP-activated protein kinase pathway and bone metabolism
They form the core of a complex regulatory network to co-ordinate metabolic activities in the cytosol with those in the mitochondria and plastids. Despite its relevance, it is still unclear when and how this regulatory pathway was formed during evolution, and to what extent its representations in the major eukaryotic lineages resemble each other. Here we have traced essential proteins forming the human AMPK—TOR pathways across species representing all three domains of life—prokaryotes bacteria, archaea and eukaryotes—and reconstructed their evolutionary history. The resulting phylogenetic profiles indicate the presence of primordial core pathways including seven proto-kinases in the last eukaryotic common ancestor.
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
Oral Communications 6. Introduction: Insulin sensitising agents are reported to have a diverse range of effects on bone with metformin exerting positive effects and thiazolidinenediones TZDs exerting negative effects. It is widely expressed in the body and can be activated by metformin. Aim: We investigated the role of AMPK pathway in mediating the effects of metformin on the osteoblast and adipocyte differentiation of mesenchymal stem cells MSCs. Cells were harvested and nuclear extracts prepared. Immunoblots were scanned using a Licor fluorescent reader. Results: MSCs treated with pioglitazone for 5 days demonstrated marked adipogenic phenotype with accumulation of lipid-rich vacuoles that stained positively with Oil Red O. Runx2 expression was unaffected by treatment with either metformin or A, suggesting that AMPK is not involved in the induction of osteogenesis in these cells. Conclusion: Metformin appears to exert its bone protective effects on MSCs by reducing adipogenesis, through activation of AMPK signalling, with no direct effect on osteogenesis. Browse other volumes.
Metformin targets multiple signaling pathways in cancer
Try out PMC Labs and tell us what you think. Learn More. AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels. Recent advancements, however, demonstrate that regulation of AMPK is also affected by novel contexts, such as subcellular localization and phosphorylation by non-canonical upstream kinases. Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation and cancer.
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial , Introducing OncoTarget. Sponsored Conferences. Impact Journals is a member of the Society for Scholarly Publishing.
Take a look at the Recent articles
These two kinases sense cellular energy and nutrient levels that in turn are determined by environmental nutrient availability. Because AMPK and mTOR are kinases, the large majority of studies remained focused on downstream substrate phosphorylation by these two proteins, and how AMPK and mTOR regulate signaling and metabolism in normal and disease physiology through phosphorylation of their substrates. Compared to the wealth of information known about the signaling and metabolic pathways modulated by these two kinases, much less is known about how the transcription of AMPK and mTOR pathway genes themselves are regulated, and the extent to which AMPK and mTOR regulate gene expression to cause durable changes in phenotype. Acute modification of cellular systems can be achieved through phosphorylation, however, induction of chronic changes requires modulation of gene expression. The seven AMPK subunits are expressed more or less ubiquitously. Both pathways can act in isolation or synergistically Woods et al. Therefore, we will not elaborate on this topic here. Instead, we will emphasize on the transcriptional regulation of the AMPK —mTOR pathway genes and how these two pathways regulate gene expression, beyond signaling.
Targeting AMPK for cancer prevention and treatment
Chinese Journal of Cancer volume 36 , Article number: 17 Cite this article. Metrics details. Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. In addition, cutting-edge targeting of cancer stem cells by metformin is summarized.
AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
RELATED VIDEO: HOW TO ACTIVATE AMPK PATHWAY - Part of the Nutrient Sensing Pathway [2020]O-linked N-acetylglucosamine, better known as O-GlcNAc, is a sugar post-translational modification participating in a diverse range of cell functions. The mammalian target of rapamycin mTOR and AMP-activated protein kinase AMPK pathways also participate in nutrient-sensing as a means of controlling cell activity and are significant factors in a variety of pathologies. Research into the individual nutrient-sensitivities of the HBP, AMPK, and mTOR pathways has revealed a complex regulatory dynamic, where their unique responses to macromolecule levels coordinate cell behavior. Importantly, cross-talk between these pathways fine-tunes the cellular response to nutrients.
AMP-activated protein kinase
Breast cancer is a highly prevalent type of cancer, which is associated with a high mortality rate and affects women worldwide 1. Genetic, metabolic and lifestyle-associated risk factors may be important in the onset and progression of breast cancer. Obesity is a risk factor that contributes to the initiation and progression of breast cancer, via increased circulation of estrogen, insulin, insulin-like growth factor and adipokines 1. Mutations in oncogenes and growth regulatory genes are further variable factors that may be associated with the development of the disease. It regulates cellular metabolism and protects living cells from the environmental stressors they may be exposed to, including hypoxia and nutrient deficiency, which lead to elevations in cellular AMP:adenosine triphosphate ratio 6. AMPK activation impairs the mammalian target of rapamycin mTOR signaling pathway, and its confirmatory p70S6 kinase and 4E-BP1 activity 7 , inhibiting protein synthesis and cell growth. Notably, low AMPK activity favors carcinogenesis 8 , 9.
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